To consider:
- If the vines have fungal damage, Copper is only a preventative for fungus like powdery mildew, not curative. If the vines already have been infected, copper will not help now. And copper can damage young growth, so don't over spray. In the Autumn, if you are in the Northern Hemisphere, of the year, when you see damage from fungus, it is too late to apply copper for those leaves. Applying fungicides now only help keep healthy leaves healthy so they can last the longest to help the plant lay down a good root system for the winter.
- While it looks like some fungal damage, if you are in the Northern Hemisphere this is also the time of year that vines leaves start to senesce, so some of this may also be normal aging. If you are in the Southern Hemisphere and you are starting the growing season, simply setup a regular spray schedule to proect the new leaves, because if those old leaves are diseased they will fall off anyway and be replaced with new healthy leaves which you want to protect.