There's multiple factors in this
Vine spacing/density, as you pointed out
Location?
How old are the vines?
What training system are you using?
Irrigation/water?
And then also keep in mind, you wont prune to your harvest-size on the first pruning. Vineyards do a few passes of fruit-dropping as the season goes on, basing the amount dropped on how the season is progressing..
If you drop too much, too soon, and the weather doesnt pan out - say those clusters raisin up, or mold over, or get attacked/eaten by wasps/birds.. Then you're short on your harvest
If you dont drop enough fruit, then the vine has a hard time ripening anything to a level that you'd want to make wine out of it
I wouldnt expect to perfect this ability on your first/second year of crops, I'm pretty sure its something you get a feel for as the years pass and one spends more time around the plants to learn what they are capable of
I'm sure I'm missing something, but I'm pretty sure there isn't any sort of formula to help with this