it is leaf phyloxria(sp). use a insecticide in your spray program to reduce damage. it can destroy the leafs to the point that nutrients for next year crop are impaired.
Marctee's picture only tells half the story and from it alone could be either phylloxera or grape blister mite. The underside of the leaf will tell the full story along with the upper part of the leaf. The mites will have colonies of mites living in clusters cauisng feeding damage which causes the blisters to form on the upper side. Phyllpoxera has blister like formations on the bottom side also and the bump contains a single larvae feeding.