Although experts say more study is warranted, and there is dissent, a lot of research suggests that the headache culprits might be histamine and tyramine, other chemical substances that are naturally present in wine. Histamine dilates blood vessels and tyramine first constricts then dilates blood vessels — ouch! Dan L. Keiller, president of the newly formed Medical Wine Interest and Education Society in San Diego, says several studies from Europe show that “red wines, in general, contain more histamine than Champagnes or sparkling wines and those usually contain more histamine than [still] white wines.” Indeed, headaches from red wine are so common that the phenomenon has its own name, “RWH syndrome”-that’s “red wine headache.” But, Dr. Keiller hastens to add, “Histamine content does not correlate consistently with color, bouquet or taste characteristics of the wine.”
People who most often have trouble with histamine in wine, Dr. Keiller and others say, are those who lack an enzyme in their intestines that can help them metabolize histamine. Tyramine, meantime, can cause your blood pressure to rise, and that triggers headaches in some people. These same people might get headaches from aged cheeses, smoked or cured meats, and citrus fruits.
Are there certain wrong steps that would cause you to get a headache? And before the comedians come out of the wood work, she was not drinking too much..... 
