A friend's wife drove a Acura MDX. It's a very nice vehicle -- very comfortable to ride in. They had it a long time and were very happy with it.
My wife & I drive Toyotas and Hondas -- mine is a 2015 Camry, 95K miles on it. Pre-COVID I drove 20K miles each year.
Secondary vehicle is a 1998 Tacoma which I purchased new and drove as a primary vehicle for 9 years, it has 196K miles on it. My previous car was a 2008 Camry, which later our sons used in college. It had 185K when we traded it in.
Wife's vehicle is 2019 Honda CR-V, which we both like. Good storage and comfortable to drive. The newer models are ahead of the curve on features and electronics. It's a 4 cylinder with a turbo, snappy acceleration, with 33+ MPG. For a smaller SUV, it's a good choice.
Her prior vehicle was a 2010 Sienna, until I went deer hunting and bagged one. Unfortunately I was driving on an interstate at the time -- I killed both the deer and the Sienna. The wife & I were shaken but unharmed -- it was an "interesting" experience but I don't advise trying it yourself. Prior to its untimely death, the Sienna had nearly 200K on it, and its predecessor (2000 Honda Odyssey) also had nearly 200K when we traded it.
If you keep vehicles long term, both Honda & Toyota are good choices. Since Acura is essentially Honda, it should be a good choice as well.
I am considering a new Tacoma for me since this is the last year for the Land Cruiser in the US and they have become absurdly expensive.
My son purchased a Tacoma last summer, he's VERY happy with it. It's funny seeing my Tacoma next to his, as the new ones are so much bigger. His truck looks like my truck's daddy.