Homemade or not, Uncle Sam doesn't know, nor care
I'll start this off by saying I'm not a lawyer, and have no great expertise in the realm of customs nor duty-free shipping, merely some experience with doing lots of border hopping.
Uncle Sam just wants your money. Duty free limits don't discriminate between beer, wine or liquor. Now, if you're willing to pay the taxes, then you can bring in anything you want, but you have to be careful about your method of transportation. If you're flying, check with their limits for baggage, since you're definitely not doing carry-on. A lot of airlines now have 50 pound limits for baggage, unless you start paying for overweight items and whatnot. I don't know what type of wine you've got, but if it's from a kit, you'd probably be better off drinking what you've already made, and remake the stuff when you're back in the US. If you're driving and you declare the amount above the duty-free limits, then you could probably claim the stuff as $5-10/bottle(assuming kit), and the ICE agent at the border crossing might just wave you through and not want to bother getting a few bucks from you.
One other wrinkle in the whole discussion is your work status when you were in Canada. I lived in Japan for a few years, and came back with a nice pile of stuff. None of it was alcohol, at least what I packed and shipped, but you're allowed duty-free for "used" household items, if you'd established residency outside the US. If you're on some NAFTA/non-visa work program, this probably doesn't apply to you.